Structural Model Analysis of Multiple Quantitative Traits
نویسندگان
چکیده
منابع مشابه
Structural Model Analysis of Multiple Quantitative Traits
We introduce a method for the analysis of multilocus, multitrait genetic data that provides an intuitive and precise characterization of genetic architecture. We show that it is possible to infer the magnitude and direction of causal relationships among multiple correlated phenotypes and illustrate the technique using body composition and bone density data from mouse intercross populations. Usi...
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To date, most genetic analyses of phenotypes have focused on analyzing single traits or analyzing each phenotype independently. However, joint epistasis analysis of multiple complementary traits will increase statistical power and improve our understanding of the complicated genetic structure of the complex diseases. Despite their importance in uncovering the genetic structure of complex traits...
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What are quantitative traits? Quantitative, or complex, traits are traits for which phenotypic variation is continuously distributed in natural populations, with population variation often approximating a statistical normal distribution on an appropriate scale. Quantitative traits include aspects of morphology (height, weight); physiology (blood pressure); behavior (aggression); as well as mole...
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متن کاملMultiple-Line Inference of Selection on Quantitative Traits.
Trait differences between species may be attributable to natural selection. However, quantifying the strength of evidence for selection acting on a particular trait is a difficult task. Here we develop a population genetics test for selection acting on a quantitative trait that is based on multiple-line crosses. We show that using multiple lines increases both the power and the scope of selecti...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2006
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.0020114